Endocrine Abstracts

Many causes of levothyroxine malabsorption have been described in the literature such as celiac disease, giardiasis, severe liver cirrhosis and drug interactions. A 27-year-old woman admitted to our institution with overt hypothyroidism symptoms. She had total thyroidectomy for thyroid papiller carcinoma and was using 400 μg/day levothyroxine (LT4). Her serum free thyroxine (fT4), free triiodothyronine (fT3) and thyrotropin stimulating hor...

The neuropsychological mechanism underlying cognitive impairment in hypothyroidism is poorly understood. It is not known whether cognitive impairment resolves following L-Thyroxine (LT4) replacement. It is also unknown whether similar neuropsychological abnormalities occur in patients with sub-clinical hypothyroidism (SCH). To address these questions, we performed neuropsychological tests in 17 patients with hypothyroidism (age 45±3 years; mean±S.E.M.)...

Clinical features associated with PCOS include obesity, hirsutism or acne, cycle abnormalities and infertility. Therefore, depending on the primary complaint these patients visit different medical specialists such as general practitioner, pediatrician, dermatologist, medical endocrinologist and gynecologist. The variability in primary complaint asks for different approaches in the work-up of these patients. Hence, doctors usually see just a proportion of the overall spectrum o...

Introduction: Marked elevation of testosterone levels can be caused by tumors with hormonal hypersecretion. However, we should be aware of the relationship between thyroid and sexual hormones, including changes of SHBG.Case report: A 48-year-old man was recommended by an urologist to endocrinological examination due to high levels of total testosterone.CT scan of abdomen, pelvis and the pituitary did not show any abnormalities....

Background: It is controversial whether symptoms of hypothyroidism and quality of life (QoL) in people with subclinical hypothyroidism (SCH) are impaired and whether treatment with L-thyroxine alleviates these. Previous studies of L-Thyroxine therapy have shown conflicting results. No previous study has simultaneously 1investigated effects of treatment on quality of life (QoL), health status, symptoms and treatment satisfaction.Methods: One hundred patie...

The cytoplasmic domains of EGF-like ligands have important biological functions. Stable transfectants of the human follicular thyroid carcinoma cell line FTC-133 over-expressing the cytoplasmic domain of proEGF (FTC-133-proEGFcyt) demonstrated a transcriptional up-regulation of the lysosomal hydrolases cathepsin- (cath-) B and -D and alterations in the processing of cath-L protein. Cath-L has strong elastinolytic activity and was the only of the three cathepsins to be secreted...

Objective: An audit comparing how the treatment of hypothyroidism has changed since the introduction of the Quality Outcome Framework (QOF) in April 2004 according to UK guidelines published by the Association of Clinical Biochemists and the British Thyroid Association (BTA) in 2005.Method: Data were collected from all patients with primary hypothyroidism in a fully computerized practice of 9830 patients under the care of 9 general practitioners. The mos...

Background: Patients with hypoparathyroidism experience significant physical and cognitive symptoms and reduced health-related quality of life (HRQoL). Conventional therapy for hypoparathyroidism does not fully alleviate diminished HRQoL. The Hypoparathyroidism Patient Experience Scales (HPES) were developed to assess disease-specific physical and cognitive symptoms as well as the impact of hypoparathyroidsm on HRQol. TransCon PTH, an investigational long-acting prodrug of par...

PARADIGHM™, a global, prospective, observational registry of patients with chronic hypoparathyroidism (HPT), began enrolment in 2013 to collect data on the natural history of chronic HPT (ClinicalTrials.gov NCT01922440). Since initiation, recombinant human PTH, rhPTH(1-84), has been approved in the United States and Europe as an adjunctive treatment for adult patients with HPT. The protocol for the registry (now a European Medicines Agency–designated postm...

BackgroundHypoparathyroidism is characterized by insufficient levels of parathyroid hormone (PTH), resulting in hypocalcemia, hyperphosphatemia, hypercalciuria, and a reduced quality of life (QoL). PTH replacement therapy should restore physiologic levels of PTH and restore downstream physiologic levels of calcitriol, promoting independence from Ca and active vitamin D supplements and normalization of QoL. TransCon PTH is an investigational long-acting p...